InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGB1BP3

Summary

InnateDB Protein

IDBP-18032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB1BP3

Protein Name

integrin beta 1 binding protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000168977

InnateDB Gene

IDBG-18030 (ITGB1BP3)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. {ECO:0000269PubMed:10613898, ECO:0000269PubMed:15137942}.

Subcellular Localization

Disease Associations

Tissue Specificity

Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta. {ECO:0000269PubMed:10613898}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0050262	ribosylnicotinamide kinase activity

Biological Process

GO:0009435	NAD biosynthetic process
GO:0016310	phosphorylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q9NPI5

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AC011488 AF190819 AK001663 AK022514 AL365377 AY611481 BC093637 BC101575 BC143329

GenPept

AAF26711 AAH93637 AAI01576 AAI43330 AAT11929 BAA91820 BAB14071 CAB96949

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca