InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tspyl2

Summary

InnateDB Protein

IDBP-180327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tspyl2

Protein Name

TSPY-like 2

Synonyms

CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E; E130307F10Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046782

InnateDB Gene

IDBG-180325 (Tspyl2)

Protein Structure

UniProt Annotation

Function

Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269PubMed:15066269}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons.

Disease Associations

Tissue Specificity

Present at high levels in the pituitary gland and at moderate levels in adrenal gland, brain, testis and ovary. In brain, expressed both in mature neurons and progenitor cells (at protein level). {ECO:0000269PubMed:12112471, ECO:0000269PubMed:15241014, ECO:0000269PubMed:16374801}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006334	nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0008156	negative regulation of DNA replication
GO:0016568	chromatin modification
GO:0030308	negative regulation of cell growth
GO:0045859	regulation of protein kinase activity