Version 5.4
Mus musculus Protein: Lalba
Summary
InnateDB Protein IDBP-180344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lalba
Protein Name lactalbumin, alpha
Synonyms AW208827;
Species Mus musculus
Ensembl Protein ENSMUSP00000023726
InnateDB Gene IDBG-180342 (Lalba)
Protein Structure
UniProt Annotation
Function Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Mammary gland specific. Secreted in milk.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004461 lactose synthase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0005989 lactose biosynthetic process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:96742
InterPro IPR000545 Lactalbumin
IPR000974 Glycoside hydrolase, family 22, lysozyme
IPR001916 Glycoside hydrolase, family 22
IPR023346 Lysozyme-like domain
PFAM PF00062
PF13406
PRINTS PR00136
PR00137
PR00135
PIRSF
SMART SM00263
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P29752
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 16770
UniGene
RefSeq NP_034809
MGI ID 2FYD
MGI Symbol Lalba
OMIM
CCDS CCDS27795
HPRD
IMGT
EMBL BC006922 BC069916 M80909 M87863
GenPept AAA37208 AAA37209 AAH06922 AAH69916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca