InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tln2

Summary

InnateDB Protein

IDBP-180378.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Tln2

Protein Name

talin 2

Synonyms

5730421P04Rik; AI507121; AI787438; AL118320; mKIAA0320;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035272

InnateDB Gene

IDBG-180368 (Tln2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005158	insulin receptor binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton

Biological Process

GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007155	cell adhesion

Cellular Component

GO:0001726	ruffle
GO:0005856	cytoskeleton
GO:0005916	fascia adherens
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:1917799

InterPro

IPR000299 FERM domain
IPR002404 Insulin receptor substrate-1, PTB
IPR002558 I/LWEQ domain
IPR006077 Vinculin/alpha-catenin
IPR015009 Vinculin-binding site-containing domain
IPR015224 Talin, central
IPR018979 FERM, N-terminal
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR029071 Ubiquitin-related domain

PFAM