InnateDB Protein
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IDBP-180485.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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St3gal3
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Protein Name
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ST3 beta-galactoside alpha-2,3-sialyltransferase 3
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Synonyms
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Siat3; Siat6; ST3GalIII; ST3N;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030263
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InnateDB Gene
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IDBG-180483 (St3gal3)
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Protein Structure
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Function |
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3- GalNAc.
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Subcellular Localization |
Membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
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Disease Associations |
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Tissue Specificity |
Found in all tissues tested. High expression found in brain, liver, kidney, colon, heart and spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003836
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beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
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GO:0008118
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N-acetyllactosaminide alpha-2,3-sialyltransferase activity
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GO:0008373
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sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1316659
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InterPro |
IPR001675
Glycosyl transferase, family 29
IPR012163
Sialyltransferase
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PFAM |
PF00777
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PRINTS |
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PIRSF |
PIRSF005557
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P97325
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PhosphoSite |
PhosphoSite-P97325
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TrEMBL |
B1AS81
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UniProt Splice Variant |
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Entrez Gene |
20441
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UniGene |
Mm.411241
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RefSeq |
NP_033202
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MGI ID |
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MGI Symbol |
St3gal3
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OMIM |
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CCDS |
CCDS18544
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HPRD |
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IMGT |
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EMBL |
AL611952
AL626764
AL627128
BC006710
CH466552
X84234
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GenPept |
AAH06710
CAA59013
CAM14710
CAM26721
CAM27383
EDL30520
EDL30522
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