Version 5.4
Mus musculus Protein: Rgs7bp
Summary
InnateDB Protein IDBP-180559.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs7bp
Protein Name regulator of G-protein signalling 7 binding protein
Synonyms A930030I01Rik; AI842293; D13Bwg1146e; R7bp;
Species Mus musculus
Ensembl Protein ENSMUSP00000066614
InnateDB Gene IDBG-180557 (Rgs7bp)
Protein Structure
UniProt Annotation
Function Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. {ECO:0000269PubMed:15897264, ECO:0000269PubMed:16574655, ECO:0000269PubMed:16867977, ECO:0000269PubMed:17158100}.
Subcellular Localization Nucleus. Cytoplasm. Cell membrane; Lipid- anchor. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation.
Disease Associations
Tissue Specificity Specifically expressed in the central nervous system including the retina but not in other non-neuronal tissues (at protein level). {ECO:0000269PubMed:15632198, ECO:0000269PubMed:15897264}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009968 negative regulation of signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:106334
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BQP9
PhosphoSite PhosphoSite-Q8BQP9
TrEMBL
UniProt Splice Variant
Entrez Gene 52882
UniGene Mm.475455
RefSeq NP_084155
MGI ID
MGI Symbol Rgs7bp
OMIM
CCDS CCDS36774
HPRD
IMGT
EMBL AK020910 AK036240 AK046733 AK137417 BC118957 DQ104214
GenPept AAI18958 AAZ09201 BAB32250 BAC29358 BAC32849 BAE23346

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca