InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr143

Summary

InnateDB Protein

IDBP-180587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr143

Protein Name

G protein-coupled receptor 143

Synonyms

Oa1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026383

InnateDB Gene

IDBG-180585 (Gpr143)

Protein Structure

UniProt Annotation

Function

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269PubMed:18697795}.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Melanosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0035240	dopamine binding
GO:0035643	L-DOPA receptor activity
GO:0072544	L-DOPA binding
GO:0072545	tyrosine binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0032400	melanosome localization
GO:0032402	melanosome transport
GO:0032438	melanosome organization
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050848	regulation of calcium-mediated signaling

Cellular Component

GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0033162	melanosome membrane
GO:0042470	melanosome