Version 5.4
Homo sapiens Protein: CLECL1
Summary
InnateDB Protein IDBP-18063.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLECL1
Protein Name C-type lectin-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331766
InnateDB Gene IDBG-18061 (CLECL1)
Protein Structure
UniProt Annotation
Function May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. {ECO:0000269PubMed:12421943}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12421943}; Single-pass type II membrane protein {ECO:0000269PubMed:12421943}.
Disease Associations
Tissue Specificity Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells. {ECO:0000269PubMed:12421943}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR016187 C-type lectin fold
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZS7
PhosphoSite PhosphoSite-Q8IZS7
TrEMBL
UniProt Splice Variant
Entrez Gene 160365
UniGene Hs.734740
RefSeq NP_742001
HUGO HGNC:24462
OMIM 607467
CCDS CCDS8603
HPRD 16247
IMGT
EMBL AF518873 BC093857 BC093859
GenPept AAH93857 AAH93859 AAN64752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca