InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf180

Summary

InnateDB Protein

IDBP-180633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf180

Protein Name

ring finger protein 180

Synonyms

3110001E11Rik; Rines;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064624

InnateDB Gene

IDBG-180627 (Rnf180)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. {ECO:0000269PubMed:18363970}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:18363970}; Single-pass membrane protein {ECO:0000269PubMed:18363970}. Nucleus envelope {ECO:0000269PubMed:18363970}.

Disease Associations

Tissue Specificity

brain, kidney, testis and uterus. membrane protein. Nucleus envelope. {ECO:0000269PubMed:18363970}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031624	ubiquitin conjugating enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0030534	adult behavior
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042415	norepinephrine metabolic process
GO:0042428	serotonin metabolic process
GO:0050790	regulation of catalytic activity
GO:1901360	organic cyclic compound metabolic process