InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmprss2

Summary

InnateDB Protein

IDBP-180658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmprss2

Protein Name

transmembrane protease, serine 2

Synonyms

D16Ertd61e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000395

InnateDB Gene

IDBG-180656 (Tmprss2)

Protein Structure

UniProt Annotation

Function

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions. The spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L- independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9) and is involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269PubMed:24227843, ECO:0000269PubMed:24348248, ECO:0000269PubMed:24522916, ECO:0000269PubMed:24600012}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Transmembrane protease serine 2 catalytic chain: Secreted {ECO:0000250}. Note=Activated by cleavage and secreted. {ECO:0000250}.

Disease Associations

Tissue Specificity

Larynx, trachea and bronchi, lung, prostate and kidney. {ECO:0000269PubMed:11169526, ECO:0000269PubMed:24522916}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0016540	protein autoprocessing
GO:0046598	positive regulation of viral entry into host cell

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1354381

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057
PF09342

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt