InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr1a

Summary

InnateDB Protein

IDBP-180679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr1a

Protein Name

5-hydroxytryptamine (serotonin) receptor 1A

Synonyms

Gpcr18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022235

InnateDB Gene

IDBG-180677 (Htr1a)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269PubMed:11080193, ECO:0000269PubMed:17543467, ECO:0000269PubMed:18599790, ECO:0000269PubMed:21508226, ECO:0000269PubMed:8254366, ECO:0000269PubMed:9826725}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:8254366}; Multi-pass membrane protein {ECO:0000269PubMed:8254366}.

Disease Associations

Tissue Specificity

Most abundantly expressed in midbrain, in dorsal raphe and hippocampus. Detected at lower levels in amygdala and brain cortex. {ECO:0000269PubMed:9826725}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0008283	cell proliferation
GO:0014062	regulation of serotonin secretion
GO:0035640	exploration behavior
GO:0042053	regulation of dopamine metabolic process
GO:0042310	vasoconstriction
GO:0042428	serotonin metabolic process
GO:0046883	regulation of hormone secretion
GO:0050795	regulation of behavior

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96273

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000610 5-Hydroxytryptamine 1A receptor
IPR000611 Neuropeptide Y receptor family
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00512
PR01012
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64264