InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ipo11

Summary

InnateDB Protein

IDBP-180730.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ipo11

Protein Name

importin 11

Synonyms

1700081H05Rik; 2510001A17Rik; AI314624; AW555235; E330021B14Rik; Ranbp11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079667

InnateDB Gene

IDBG-180728 (Ipo11)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPL12, and of UBE2E3 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity

Biological Process

GO:0006610	ribosomal protein import into nucleus
GO:0006886	intracellular protein transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2442377

InterPro

IPR001494 Importin-beta, N-terminal domain
IPR016024 Armadillo-type fold

PFAM

PF03810

PRINTS

PIRSF

SMART

SM00913

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K2V6

PhosphoSite

PhosphoSite-Q8K2V6

TrEMBL

UniProt Splice Variant

Entrez Gene

76582

UniGene

Mm.417493

RefSeq

NP_083941

MGI ID

MGI Symbol

Ipo11

OMIM

CCDS

CCDS36776

HPRD

IMGT

EMBL

AK087793 BC029746 BC031900

GenPept

AAH29746 AAH31900 BAC40005