Version 5.4
Homo sapiens Protein: CD69
Summary
InnateDB Protein IDBP-18079.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD69
Protein Name CD69 molecule
Synonyms AIM; BL-AC/P26; CLEC2C; EA1; GP32/28; MLR-3;
Species Homo sapiens
Ensembl Protein ENSP00000228434
InnateDB Gene IDBG-18077 (CD69)
Protein Structure
UniProt Annotation
Function Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 2 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005509 calcium ion binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007165 signal transduction
GO:0035690 cellular response to drug
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR008646 Herpesvirus UL45-like
IPR016187 C-type lectin fold
PFAM PF00059
PF05473
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q07108
PhosphoSite PhosphoSite-Q07108
TrEMBL Q6LAB3
UniProt Splice Variant
Entrez Gene 969
UniGene Hs.706997
RefSeq NP_001772
HUGO HGNC:1694
OMIM 107273
CCDS CCDS8604
HPRD 00119
IMGT
EMBL AC007068 AK291869 AK303174 AY238518 BC007037 CH471094 L07555 Z22576 Z30426 Z30427 Z30428 Z30429 Z30430 Z38109
GenPept AAB46359 AAH07037 AAO63584 BAF84558 BAG64271 CAA80298 CAA83017 CAA86225 EAW96122 EAW96123

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca