InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 4930506M07Rik

Summary

InnateDB Protein

IDBP-180894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

4930506M07Rik

Protein Name

RIKEN cDNA 4930506M07 gene

Synonyms

mKIAA1598; Shootin1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041378

InnateDB Gene

IDBG-180892 (4930506M07Rik)

Protein Structure

UniProt Annotation

Function

Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K Activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, axon {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019900	kinase binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0048812	neuron projection morphogenesis
GO:0051899	membrane depolarization
GO:2000114	regulation of establishment of cell polarity
GO:2001222	regulation of neuron migration