InnateDB Protein
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IDBP-181003.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ric8b
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Protein Name
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resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000046981
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InnateDB Gene
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IDBG-181001 (Ric8b)
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Protein Structure
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Function |
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha- dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. {ECO:0000250, ECO:0000269PubMed:15829631}.
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Subcellular Localization |
Cytoplasm, cell cortex {ECO:0000250}. Note=Localizes to the cell cortex. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in the mature olfactory sensory neurons and also in a few regions in the brain. {ECO:0000269PubMed:15829631}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0043087
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regulation of GTPase activity
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Cellular Component |
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PDB ID |
MGI:2682307
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InterPro |
IPR008376
Synembryn
IPR016024
Armadillo-type fold
IPR019318
Guanine nucleotide exchange factor, Ric8
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PFAM |
PF10165
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PRINTS |
PR01802
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q80XE1
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PhosphoSite |
PhosphoSite-Q80XE1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
237422
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UniGene |
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RefSeq |
NP_898995
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MGI ID |
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MGI Symbol |
Ric8b
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OMIM |
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CCDS |
CCDS24085
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HPRD |
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IMGT |
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EMBL |
AK132369
AY940666
AY940667
BC051080
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GenPept |
AAH51080
AAX46315
AAX46316
BAE21130
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