InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ric8b

Summary

InnateDB Protein

IDBP-181005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ric8b

Protein Name

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093032

InnateDB Gene

IDBG-181001 (Ric8b)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha- dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. {ECO:0000250, ECO:0000269PubMed:15829631}.

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000250}. Note=Localizes to the cell cortex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in the mature olfactory sensory neurons and also in a few regions in the brain. {ECO:0000269PubMed:15829631}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0043087	regulation of GTPase activity

Cellular Component

GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex

Protein Structure and Domains

PDB ID

MGI:2682307

InterPro

IPR008376 Synembryn
IPR016024 Armadillo-type fold
IPR019318 Guanine nucleotide exchange factor, Ric8

PFAM

PF10165

PRINTS

PR01802

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80XE1

PhosphoSite

PhosphoSite-Q80XE1

TrEMBL

UniProt Splice Variant

Entrez Gene

237422

UniGene

RefSeq

NP_001013459

MGI ID

MGI Symbol

Ric8b

OMIM

CCDS

CCDS24084

HPRD

IMGT

EMBL

AK132369 AY940666 AY940667 BC051080

GenPept

AAH51080 AAX46315 AAX46316 BAE21130