InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnk18

Summary

InnateDB Protein

IDBP-181027.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnk18

Protein Name

potassium channel, subfamily K, member 18

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065713

InnateDB Gene

IDBG-181025 (Kcnk18)

Protein Structure

UniProt Annotation

Function

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation. {ECO:0000269PubMed:14981085, ECO:0000269PubMed:16192517, ECO:0000269PubMed:18568022}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20006580}; Multi-pass membrane protein {ECO:0000269PubMed:20006580}.

Disease Associations

Tissue Specificity

Detected in brain cortex, cerebellum, dorsal root ganglion, spinal cord and testis. High expression in trigeminal ganglion, also expressed in autonomic nervous system ganglia such as the stellate ganglion and paravertebral sympathetic ganglia. Expressed in all adult spinal cord and brain regions, with slightly higher expression in thalamus, hypothalamus, hippocampus and posterior corte (at protein level). In non-neuronal tissues, substantial expression found in lung and heart and weal expression in liver, testis, kidney, small intestine and spleen. {ECO:0000269PubMed:14981085, ECO:0000269PubMed:16192517, ECO:0000269PubMed:17962323, ECO:0000269PubMed:20871611}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015269	calcium-activated potassium channel activity
GO:0015271	outward rectifier potassium channel activity

Biological Process

GO:0006813	potassium ion transport
GO:0071435	potassium ion export
GO:0071467	cellular response to pH

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2685627

InterPro

IPR003092 Two pore domain potassium channel, TASK family
IPR003280 Two pore domain potassium channel
IPR013099 Two pore domain potassium channel domain

PFAM

PF07885

PRINTS

PR01095
PR01333

PIRSF

PIRSF038061

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt