InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGER4

Summary

InnateDB Protein

IDBP-18108.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGER4

Protein Name

prostaglandin E receptor 4 (subtype EP4)

Synonyms

EP4; EP4R;

Species

Homo sapiens

Ensembl Protein

ENSP00000302846

InnateDB Gene

IDBG-18106 (PTGER4)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007254	JNK cascade
GO:0009612	response to mechanical stimulus
GO:0030278	regulation of ossification
GO:0032496	response to lipopolysaccharide
GO:0033624	negative regulation of integrin activation
GO:0042093	T-helper cell differentiation
GO:0045087	innate immune response
GO:0050710	negative regulation of cytokine secretion
GO:0050715	positive regulation of cytokine secretion
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051492	regulation of stress fiber assembly
GO:0060348	bone development
GO:0070371	ERK1 and ERK2 cascade
GO:0071260	cellular response to mechanical stimulus
GO:2000420	negative regulation of eosinophil extravasation

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001244 Prostaglandin DP receptor
IPR001758 Prostanoid EP4 receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10328

PRINTS

PR00237
PR00428
PR00586
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35408