InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxcl13

Summary

InnateDB Protein

IDBP-181229.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcl13

Protein Name

chemokine (C-X-C motif) ligand 13

Synonyms

4631412M08Rik; Angie; ANGIE2; BCA-1; BLC; BLR1L; Scyb13;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023840

InnateDB Gene

IDBG-181227 (Cxcl13)

Protein Structure

UniProt Annotation

Function

Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0017134	fibroblast growth factor binding
GO:0031724	CXCR5 chemokine receptor binding
GO:0031735	CCR10 chemokine receptor binding
GO:0046982	protein heterodimerization activity
GO:0048018	receptor agonist activity
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0002518	lymphocyte chemotaxis across high endothelial venule
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0010820	positive regulation of T cell chemotaxis
GO:0032861	activation of Rap GTPase activity
GO:0033625	positive regulation of integrin activation
GO:0033634	positive regulation of cell-cell adhesion mediated by integrin
GO:0035754	B cell chemotaxis
GO:0035768	endothelial cell chemotaxis to fibroblast growth factor
GO:0035769	B cell chemotaxis across high endothelial venule
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0048535	lymph node development
GO:0070098	chemokine-mediated signaling pathway
GO:2000545	negative regulation of endothelial cell chemotaxis to fibroblast growth factor