InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sat1

Summary

InnateDB Protein

IDBP-181247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sat1

Protein Name

spermidine/spermine N1-acetyl transferase 1

Synonyms

AA617398; Sat; SSAT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026318

InnateDB Gene

IDBG-181245 (Sat1)

Protein Structure

UniProt Annotation

Function

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004145	diamine N-acetyltransferase activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0019809	spermidine binding

Biological Process

GO:0001525	angiogenesis
GO:0006595	polyamine metabolic process
GO:0006598	polyamine catabolic process
GO:0009447	putrescine catabolic process
GO:0032918	spermidine acetylation
GO:0042127	regulation of cell proliferation
GO:0046208	spermine catabolic process