Version 5.4
Mus musculus Protein: Szt2
Summary
InnateDB Protein IDBP-181266.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Szt2
Protein Name seizure threshold 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000074862
InnateDB Gene IDBG-181052 (Szt2)
Protein Structure
UniProt Annotation
Function Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and confer low seizure threshold. {ECO:0000269PubMed:19624305, ECO:0000269PubMed:20045724}.
Subcellular Localization Peroxisome {ECO:0000269PubMed:20045724}.
Disease Associations
Tissue Specificity Mostly expressed in brain, spinal cord and lung. {ECO:0000269PubMed:19624305, ECO:0000269PubMed:20045724}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007417 central nervous system development
GO:0009790 embryo development
GO:0009791 post-embryonic development
GO:0021540 corpus callosum morphogenesis
GO:0043473 pigmentation
GO:1901668 regulation of superoxide dismutase activity
Cellular Component
GO:0005777 peroxisome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:3033336
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2A9C3
PhosphoSite PhosphoSite-NP_937813
TrEMBL
UniProt Splice Variant
Entrez Gene 230676
UniGene Mm.415218
RefSeq NP_937813
MGI ID
MGI Symbol Szt2
OMIM
CCDS CCDS51283
HPRD
IMGT
EMBL AL627212 BC052935 BC059842 FJ998170 GU433214
GenPept AAH52935 AAH59842 ACS91341 CAM15198

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca