InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gtf2f2

Summary

InnateDB Protein

IDBP-181299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gtf2f2

Protein Name

general transcription factor IIF, polypeptide 2

Synonyms

1110031C13Rik; AI326315;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086312

InnateDB Gene

IDBG-181297 (Gtf2f2)

Protein Structure

UniProt Annotation

Function

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA- helicase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005674	transcription factor TFIIF complex
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1915955

InterPro

IPR003196 Transcription initiation factor IIF, beta subunit
IPR011039 Transcription Factor IIF, Rap30/Rap74, interaction
IPR016640 Transcription initiation factor IIF, beta subunit, subgroup

PFAM

PF02270

PRINTS

PIRSF

PIRSF015849

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R0A0