InnateDB Protein
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IDBP-181348.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Med8
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Protein Name
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mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)
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Synonyms
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2210021A15Rik; AB041805; ARC32;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000019229
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InnateDB Gene
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IDBG-181342 (Med8)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
52 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0005515
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protein binding
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0016567
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protein ubiquitination
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Cellular Component |
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PDB ID |
MGI:1915269
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InterPro |
IPR019364
Mediator complex, subunit Med8, fungi/metazoa
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PFAM |
PF10232
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D7W5
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PhosphoSite |
PhosphoSite-Q9D7W5
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TrEMBL |
Q9CY05
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UniProt Splice Variant |
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Entrez Gene |
80509
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UniGene |
Mm.259567
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RefSeq |
NP_064384
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MGI ID |
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MGI Symbol |
Med8
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OMIM |
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CCDS |
CCDS38854
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HPRD |
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IMGT |
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EMBL |
AB041805
AK008759
AK011080
AK147032
AK148025
AL627212
BC002315
BC021870
CH466552
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GenPept |
AAH02315
AAH21870
BAA95113
BAB25879
BAB27384
BAE27624
BAE28295
EDL30509
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