Version 5.4
Mus musculus Protein: Elovl1
Summary
InnateDB Protein IDBP-181449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elovl1
Protein Name elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
Synonyms AA407424; BB151133; Ssc1;
Species Mus musculus
Ensembl Protein ENSMUSP00000006557
InnateDB Gene IDBG-181447 (Elovl1)
Protein Structure
UniProt Annotation
Function Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000269PubMed:10791983, ECO:0000269PubMed:23407971}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in a broad variety of tissues. Highly expressed in stomach, lung, kidney, skin and intestine. Moderately expressed in white adipose tissue, liver, spleen, brain, brown adipose tissue, heart and muscle. Weakly expressed in testis. {ECO:0000269PubMed:10791983}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009922 fatty acid elongase activity
Biological Process
GO:0019367 fatty acid elongation, saturated fatty acid
GO:0030148 sphingolipid biosynthetic process
GO:0034625 fatty acid elongation, monounsaturated fatty acid
GO:0042761 very long-chain fatty acid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1858959
InterPro IPR002076 GNS1/SUR4 membrane protein
PFAM PF01151
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JLJ5
PhosphoSite PhosphoSite-
TrEMBL Q548M4
UniProt Splice Variant
Entrez Gene 54325
UniGene
RefSeq NP_062295
MGI ID
MGI Symbol Elovl1
OMIM
CCDS CCDS18549
HPRD
IMGT
EMBL AF170907 AF322919 AK003743 AK135348 AK156003 AK171217 BC006735 CH466552
GenPept AAF72572 AAH06735 AAL73137 BAB22975 BAE22497 BAE33541 BAE42321 EDL30504 EDL30505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca