InnateDB Protein
|
IDBP-181485.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Nfe2l2
|
Protein Name
|
nuclear factor, erythroid derived 2, like 2
|
Synonyms
|
AI194320; Nrf2;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000099733
|
InnateDB Gene
|
IDBG-181483 (Nfe2l2)
|
Protein Structure
|
|
Function |
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. {ECO:0000269PubMed:9887101}.
|
Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:9887101}. Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:9887101}. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. Highest expression in liver, skeletal muscle, luminal cells of the stomach and intestine, lining of the bronchi and alveoli, and in renal tubules; followed by heart, spleen, testis and brain.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated |
Total |
38
[view]
|
Protein-Protein |
34
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
46 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000976
|
transcription regulatory region sequence-specific DNA binding
|
GO:0000980
|
RNA polymerase II distal enhancer sequence-specific DNA binding
|
GO:0001102
|
RNA polymerase II activating transcription factor binding
|
GO:0001205
|
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0001221
|
transcription cofactor binding
|
GO:0003677
|
DNA binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0005515
|
protein binding
|
GO:0019904
|
protein domain specific binding
|
GO:0043565
|
sequence-specific DNA binding
|
|
Biological Process |
GO:0006351
|
transcription, DNA-templated
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0010499
|
proteasomal ubiquitin-independent protein catabolic process
|
GO:0016567
|
protein ubiquitination
|
GO:0030194
|
positive regulation of blood coagulation
|
GO:0030968
|
endoplasmic reticulum unfolded protein response
|
GO:0034599
|
cellular response to oxidative stress
|
GO:0036003
|
positive regulation of transcription from RNA polymerase II promoter in response to stress
|
GO:0036091
|
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
|
GO:0043161
|
proteasome-mediated ubiquitin-dependent protein catabolic process
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0045893
|
positive regulation of transcription, DNA-templated
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0045995
|
regulation of embryonic development
|
GO:0060548
|
negative regulation of cell death
|
GO:0070301
|
cellular response to hydrogen peroxide
|
GO:0071356
|
cellular response to tumor necrosis factor
|
GO:0071499
|
cellular response to laminar fluid shear stress
|
GO:1902176
|
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
|
GO:2000121
|
regulation of removal of superoxide radicals
|
GO:2000352
|
negative regulation of endothelial cell apoptotic process
|
GO:2000379
|
positive regulation of reactive oxygen species metabolic process
|
|
Cellular Component |
|
PDB ID |
MGI:108420
|
InterPro |
IPR004827
Basic-leucine zipper domain
IPR008917
Transcription factor, Skn-1-like, DNA-binding domain
|
PFAM |
PF00170
PF07716
|
PRINTS |
|
PIRSF |
|
SMART |
SM00338
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q60795
|
PhosphoSite |
PhosphoSite-Q60795
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
18024
|
UniGene |
Mm.1025
|
RefSeq |
NP_035032
|
MGI ID |
3WN7
|
MGI Symbol |
Nfe2l2
|
OMIM |
|
CCDS |
CCDS16150
|
HPRD |
|
IMGT |
|
EMBL |
AK142347
AL772404
BC026943
U20532
U70474
U70475
|
GenPept |
AAA68291
AAC52983
AAH26943
BAE25040
CAM22493
|
|
|