Mus musculus Protein: Nfe2l2
Summary
InnateDB Protein IDBP-181485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfe2l2
Protein Name nuclear factor, erythroid derived 2, like 2
Synonyms AI194320; Nrf2;
Species Mus musculus
Ensembl Protein ENSMUSP00000099733
InnateDB Gene IDBG-181483 (Nfe2l2)
Protein Structure
UniProt Annotation
Function Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. {ECO:0000269PubMed:9887101}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:9887101}. Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:9887101}. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Disease Associations
Tissue Specificity Widely expressed. Highest expression in liver, skeletal muscle, luminal cells of the stomach and intestine, lining of the bronchi and alveoli, and in renal tubules; followed by heart, spleen, testis and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 34 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001221 transcription cofactor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030194 positive regulation of blood coagulation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034599 cellular response to oxidative stress
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045995 regulation of embryonic development
GO:0060548 negative regulation of cell death
GO:0070301 cellular response to hydrogen peroxide
GO:0071356 cellular response to tumor necrosis factor
GO:0071499 cellular response to laminar fluid shear stress
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000121 regulation of removal of superoxide radicals
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:108420
InterPro IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
PFAM PF00170
PF07716
PRINTS
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60795
PhosphoSite PhosphoSite-Q60795
TrEMBL
UniProt Splice Variant
Entrez Gene 18024
UniGene Mm.1025
RefSeq NP_035032
MGI ID 3WN7
MGI Symbol Nfe2l2
OMIM
CCDS CCDS16150
HPRD
IMGT
EMBL AK142347 AL772404 BC026943 U20532 U70474 U70475
GenPept AAA68291 AAC52983 AAH26943 BAE25040 CAM22493