InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flii

Summary

InnateDB Protein

IDBP-181505.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flii

Protein Name

flightless I homolog (Drosophila)

Synonyms

3632430F08Rik; Fliih;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002889

InnateDB Gene

IDBG-181503 (Flii)

Protein Structure

UniProt Annotation

Function

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity). Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. {ECO:0000250, ECO:0000269PubMed:11171324, ECO:0000269PubMed:11971982, ECO:0000269PubMed:21430700, ECO:0000269PubMed:22581781}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes.

Disease Associations

Tissue Specificity

Expressed in blastocyst. {ECO:0000269PubMed:10947868}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0030036	actin cytoskeleton organization
GO:0051014	actin filament severing