Version 5.4
Mus musculus Protein: Nanos1
Summary
InnateDB Protein IDBP-181602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nanos1
Protein Name nanos homolog 1 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096874
InnateDB Gene IDBG-181600 (Nanos1)
Protein Structure
UniProt Annotation
Function May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion (By similarity). Not essential for normal development. {ECO:0000250, ECO:0000269PubMed:12834871}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the oocyte. Transiently expressed in eight-cell embryos. At 12.5 dpc, it is re-expressed in the central nervous system and the expression continues in the adult brain, in which the hippocampal formation is the predominant region. Expressed in the seminiferous tubules of mature testis, but not in the primordial germ cells. {ECO:0000269PubMed:12834871}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030371 translation repressor activity
Biological Process
GO:0010631 epithelial cell migration
GO:0016477 cell migration
GO:0017148 negative regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2669254
InterPro IPR024161 Zinc finger, nanos-type
PFAM PF05741
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80WY3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 332397
UniGene Mm.186390
RefSeq NP_848508
MGI ID
MGI Symbol Nanos1
OMIM
CCDS CCDS29941
HPRD
IMGT
EMBL AB095029 AK139148 BC056473 BC085512 CD350545
GenPept AAH56473 AAH85512 BAC76003 BAE23901

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca