InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif3a

Summary

InnateDB Protein

IDBP-181611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif3a

Protein Name

eukaryotic translation initiation factor 3, subunit A

Synonyms

A830012B05Rik; Csma; Eif3; Eif3s10; mKIAA0139;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025955

InnateDB Gene

IDBG-181609 (Eif3a)

Protein Structure

UniProt Annotation

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03000}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:9372446}. Nucleus {ECO:0000269PubMed:9372446}. Note=Centrosomin-A is found in the centrosome. Centrosomin-B is found in the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0001732	formation of translation initiation complex
GO:0006446	regulation of translational initiation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0016020	membrane
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m