Version 5.4
Mus musculus Protein: Olfml3
Summary
InnateDB Protein IDBP-181617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Olfml3
Protein Name olfactomedin-like 3
Synonyms 2810002E22Rik; AI115209; AW550633; HNOEL-iso; mONT3; ONT3;
Species Mus musculus
Ensembl Protein ENSMUSP00000029440
InnateDB Gene IDBG-181615 (Olfml3)
Protein Structure
UniProt Annotation
Function Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:1914877
InterPro IPR003112 Olfactomedin-like
PFAM PF02191
PRINTS
PIRSF
SMART SM00284
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BK62
PhosphoSite PhosphoSite-Q8BK62
TrEMBL
UniProt Splice Variant
Entrez Gene 99543
UniGene Mm.406214
RefSeq NP_598620
MGI ID
MGI Symbol Olfml3
OMIM
CCDS CCDS17693
HPRD
IMGT
EMBL AK002518 AK076084 AK131879 BC005485 CU210935
GenPept AAH05485 BAC24996 BAC36170 BAE20846 CAP58491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca