Version 5.4
Mus musculus Protein: Mt2
Summary
InnateDB Protein IDBP-181672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mt2
Protein Name metallothionein 2
Synonyms AA409533; Mt-2; MT-II;
Species Mus musculus
Ensembl Protein ENSMUSP00000034214
InnateDB Gene IDBG-181670 (Mt2)
Protein Structure
UniProt Annotation
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006882 cellular zinc ion homeostasis
GO:0007263 nitric oxide mediated signal transduction
GO:0010273 detoxification of copper ion
GO:0036018 cellular response to erythropoietin
GO:0045926 negative regulation of growth
GO:0071276 cellular response to cadmium ion
GO:0071294 cellular response to zinc ion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:97172
InterPro IPR000006 Metallothionein, vertebrate
IPR003019 Metallothionein superfamily, eukaryotic
IPR017854 Metallothionein domain
PFAM PF00131
PRINTS PR00860
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02798
PhosphoSite PhosphoSite-P02798
TrEMBL
UniProt Splice Variant
Entrez Gene 17750
UniGene
RefSeq NP_032656
MGI ID
MGI Symbol Mt2
OMIM
CCDS CCDS40437
HPRD
IMGT
EMBL AK002567 BC031758 K02236
GenPept AAA39528 AAH31758 BAB22192

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca