InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smcr7

Summary

InnateDB Protein

IDBP-181681.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smcr7

Protein Name

Smith-Magenis syndrome chromosome region, candidate 7 homolog (human)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018743

InnateDB Gene

IDBG-181679 (Smcr7)

Protein Structure

UniProt Annotation

Function

Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269PubMed:23283981, ECO:0000269PubMed:24508339}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:24508339}; Single-pass membrane protein {ECO:0000269PubMed:24508339}. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0007005	mitochondrion organization
GO:0032464	positive regulation of protein homooligomerization
GO:0090141	positive regulation of mitochondrial fission
GO:0090314	positive regulation of protein targeting to membrane