InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde4d

Summary

InnateDB Protein

IDBP-181736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde4d

Protein Name

phosphodiesterase 4D, cAMP specific

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073742

InnateDB Gene

IDBG-181732 (Pde4d)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Apical cell membrane {ECO:0000250}. Note=Colocalized with SHANK2 to the apical membrane of colonic crypt cells (By similarity). Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis. {ECO:0000269PubMed:12834813, ECO:0000269PubMed:17244609}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030552	cAMP binding
GO:0031625	ubiquitin protein ligase binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding
GO:0051117	ATPase binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002027	regulation of heart rate
GO:0006198	cAMP catabolic process
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007568	aging
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0030593	neutrophil chemotaxis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0032754	positive regulation of interleukin-5 production
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035264	multicellular organism growth
GO:0045822	negative regulation of heart contraction
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028	establishment of endothelial barrier
GO:0071222	cellular response to lipopolysaccharide
GO:0071320	cellular response to cAMP
GO:0071872	cellular response to epinephrine stimulus
GO:0086004	regulation of cardiac muscle cell contraction
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898	negative regulation of relaxation of cardiac muscle

Cellular Component

GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005891	voltage-gated calcium channel complex
GO:0016324	apical plasma membrane
GO:0034704	calcium channel complex