InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyct

Summary

InnateDB Protein

IDBP-181750.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyct

Protein Name

cytochrome c, testis

Synonyms

T-Cc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028430

InnateDB Gene

IDBG-181748 (Cyct)

Protein Structure

UniProt Annotation

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

Disease Associations

Tissue Specificity

This is one of two isocytochromes C found in the testis. The other is identical with the form found in other mouse tissues. These cytochromes are assumed to be located in the sperm.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0009055	electron carrier activity
GO:0020037	heme binding

Biological Process

GO:0006915	apoptotic process
GO:0042743	hydrogen peroxide metabolic process
GO:0055114	oxidation-reduction process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway