InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim40

Summary

InnateDB Protein

IDBP-181802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim40

Protein Name

tripartite motif-containing 40

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084400

InnateDB Gene

IDBG-181800 (Trim40)

Protein Structure

UniProt Annotation

Function

May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0030308	negative regulation of cell growth
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0042177	negative regulation of protein catabolic process
GO:0045116	protein neddylation
GO:1900181	negative regulation of protein localization to nucleus