InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim31

Summary

InnateDB Protein

IDBP-181834.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim31

Protein Name

tripartite motif-containing 31

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077535

InnateDB Gene

IDBG-181832 (Trim31)

Protein Structure

UniProt Annotation

Function

May have E3 ubiquitin-protein ligase activity (By similarity). Regulator of Src-induced anchorage independent cell growth. {ECO:0000250, ECO:0000269PubMed:19665990}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Predomintanly expressed in the cytoplasm but a fraction is associated with the mitochondria. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the gastrointestrinal tract, with high expression in the small intestine, moderate in the large intestine and weak in the stomach and esophagus. {ECO:0000269PubMed:19665990}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032897	negative regulation of viral transcription
GO:0045087	innate immune response
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:1902186	regulation of viral release from host cell

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:2385051

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt