InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc17a7

Summary

InnateDB Protein

IDBP-181907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc17a7

Protein Name

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

Synonyms

2900052E22Rik; AI851913; Vglut1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082489

InnateDB Gene

IDBG-181905 (Slc17a7)

Protein Structure

UniProt Annotation

Function

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269PubMed:15103023, ECO:0000269PubMed:15118123, ECO:0000269PubMed:17611277}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome.

Disease Associations

Tissue Specificity

Expressed in hippocampus (at protein level). Expressed in the molecular layer of the cerebellum and in retina. {ECO:0000269PubMed:15103023, ECO:0000269PubMed:16595674, ECO:0000269PubMed:17611277, ECO:0000269PubMed:24153177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005315	inorganic phosphate transmembrane transporter activity
GO:0015319	sodium:inorganic phosphate symporter activity
GO:0015321	sodium-dependent phosphate transmembrane transporter activity

Biological Process

GO:0006817	phosphate ion transport
GO:0006836	neurotransmitter transport
GO:0007268	synaptic transmission
GO:0007616	long-term memory
GO:0035249	synaptic transmission, glutamatergic
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042137	sequestering of neurotransmitter
GO:0044341	sodium-dependent phosphate transport
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0043229	intracellular organelle
GO:0044300	cerebellar mossy fiber
GO:0045202	synapse
GO:0048786	presynaptic active zone
GO:0060076	excitatory synapse

Protein Structure and Domains

PDB ID

MGI:1920211

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3TXX4

PhosphoSite