Version 5.4
Mus musculus Protein: Gapt
Summary
InnateDB Protein IDBP-181931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gapt
Protein Name Grb2-binding adaptor, transmembrane
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000053775
InnateDB Gene IDBG-181929 (Gapt)
Protein Structure
UniProt Annotation
Function Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells. {ECO:0000269PubMed:18559951}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed primarily in B220+ splenocytes and total bone marrow cells. Expressed at lower levels in mast cells and dendritic cells. Not detected in T-cells and macrophages (at protein level). {ECO:0000269PubMed:18559951}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0042113 B cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3608341
InterPro IPR021082 Protein GAPT
PFAM PF11770
PRINTS PR02077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CB93
PhosphoSite PhosphoSite-Q8CB93
TrEMBL
UniProt Splice Variant
Entrez Gene 238875
UniGene Mm.30533
RefSeq NP_808381
MGI ID
MGI Symbol Gapt
OMIM
CCDS CCDS26766
HPRD
IMGT
EMBL AK036534 AK155882 BC116629 BC118005
GenPept AAI16630 AAI18006 BAC29466 BAE33480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca