InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpn22

Summary

InnateDB Protein

IDBP-181954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn22

Protein Name

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Synonyms

70zpep; PEP; Ptpn8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029433

InnateDB Gene

IDBG-181952 (Ptpn22)

Protein Structure

UniProt Annotation

Function

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-492' residue. Dephosphorylates the immune system activator SKAP2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:8890164}.

Disease Associations

Tissue Specificity

Spleen, thymus, lymph node and bone marrow.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017124	SH3 domain binding
GO:0019900	kinase binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0030217	T cell differentiation
GO:0032817	regulation of natural killer cell proliferation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035644	phosphoanandamide dephosphorylation
GO:0050852	T cell receptor signaling pathway
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050868	negative regulation of T cell activation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009898	cytoplasmic side of plasma membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:107170

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR016276 Non-receptor tyrosine-protein phosphatase, 8/22
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700

PIRSF

PIRSF000930

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References