InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gcnt3

Summary

InnateDB Protein

IDBP-181969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gcnt3

Protein Name

glucosaminyl (N-acetyl) transferase 3, mucin type

Synonyms

2010013H22Rik; 2210021I22Rik; 2210401J11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034751

InnateDB Gene

IDBG-181967 (Gcnt3)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375	acetylglucosaminyltransferase activity
GO:0047225	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

Biological Process

GO:0002426	immunoglobulin production in mucosal tissue
GO:0006486	protein glycosylation
GO:0048729	tissue morphogenesis
GO:0050892	intestinal absorption
GO:0060993	kidney morphogenesis