InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacna1c

Summary

InnateDB Protein

IDBP-182007.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacna1c

Protein Name

calcium channel, voltage-dependent, L type, alpha 1C subunit

Synonyms

Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075021

InnateDB Gene

IDBG-182003 (Cacna1c)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006939	smooth muscle contraction
GO:0007268	synaptic transmission
GO:0007628	adult walking behavior
GO:0008217	regulation of blood pressure
GO:0008542	visual learning
GO:0017156	calcium ion-dependent exocytosis
GO:0019229	regulation of vasoconstriction
GO:0030073	insulin secretion
GO:0030252	growth hormone secretion
GO:0034765	regulation of ion transmembrane transport
GO:0042593	glucose homeostasis
GO:0046620	regulation of organ growth
GO:0055085	transmembrane transport
GO:0060083	smooth muscle contraction involved in micturition
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0002095	caveolar macromolecular signaling complex
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft

Protein Structure and Domains

PDB ID

MGI:103013

InterPro

IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
IPR005451 Voltage-dependent calcium channel, L-type, alpha-1C subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00520
PF08016
PF08763

PRINTS

PR00167
PR01630
PR01635

PIRSF

SMART

SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F8WIW9

UniProt Splice Variant

Entrez Gene

12288

UniGene

Mm.436656

RefSeq

MGI ID

MGI Symbol

Cacna1c

OMIM

CCDS

HPRD

IMGT

EMBL

AC036121 AC127328 L01776 L06233 M57973 U17869

GenPept

AAA37351 AAA62612 AAA63291 AAB59633