InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf111

Summary

InnateDB Protein

IDBP-182245.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf111

Protein Name

ring finger 111

Synonyms

ARK; Arkadia;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034739

InnateDB Gene

IDBG-182243 (Rnf111)

Protein Structure

UniProt Annotation

Function

Acts in the Nodal pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14657019}. Cytoplasm {ECO:0000250}. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11298452}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0032184	SUMO polymer binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0007389	pattern specification process
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0045893	positive regulation of transcription, DNA-templated