InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttn

Summary

InnateDB Protein

IDBP-182302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttn

Protein Name

titin

Synonyms

1100001C23Rik; 2310036G12Rik; 2310057K23Rik; 2310074I15Rik; AF006999; AV006427; D330041I19Rik; D830007G01Rik; L56; mdm; shru;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000011934

InnateDB Gene

IDBG-182351 (Ttn)

Protein Structure

UniProt Annotation

Function

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000250UniProtKB:Q8WZ42, ECO:0000269PubMed:16702235, ECO:0000269PubMed:17261657}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250UniProtKB:Q8WZ42}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030506	ankyrin binding
GO:0046872	metal ion binding

Biological Process

GO:0001756	somitogenesis
GO:0006468	protein phosphorylation
GO:0007507	heart development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:1901897	regulation of relaxation of cardiac muscle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:98864

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002035 von Willebrand factor, type A
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR012337 Ribonuclease H-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR015129 Titin Z
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM