Version 5.4
Mus musculus Protein: C1ql4
Summary
InnateDB Protein IDBP-182321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1ql4
Protein Name complement component 1, q subcomponent-like 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000068402
InnateDB Gene IDBG-182319 (C1ql4)
Protein Structure
UniProt Annotation
Function May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. May inhibit adipocyte differentiation at an early stage of the process. {ECO:0000269PubMed:21262840, ECO:0000269PubMed:23449976}.
Subcellular Localization Secreted {ECO:0000269PubMed:23449976}.
Disease Associations
Tissue Specificity Highly expressed in testis and adipose tissue, brown adipose tissue expressing higher levels than subcutaneous and visceral white adipose tissue. In gonadal fat pad, expressed at lower levels in adipocytes than in the stromal vascular fraction (VSP), which contains preadipocytes, fibroblasts, endothelial cells and occasional immune cells. Expression exhibits sexually dimorphism, with higher levels in females than in males. {ECO:0000269PubMed:23449976}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0005581 collagen trimer
Protein Structure and Domains
PDB ID MGI:3579909
InterPro IPR001073 Complement C1q protein
IPR008983 Tumour necrosis factor-like domain
PFAM PF00386
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4ZJM9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 239659
UniGene Mm.309917
RefSeq NP_001019873
MGI ID
MGI Symbol C1ql4
OMIM
CCDS CCDS27814
HPRD
IMGT
EMBL BC147036 BC147037 CH466550 DQ002403
GenPept AAI47037 AAI47038 AAY21935 EDL04144

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca