InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aldh3a1

Summary

InnateDB Protein

IDBP-182379.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh3a1

Protein Name

aldehyde dehydrogenase family 3, subfamily A1

Synonyms

Ahd-4; Ahd4; Aldh; Aldh3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019246

InnateDB Gene

IDBG-182377 (Aldh3a1)

Protein Structure

UniProt Annotation

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes and in preventing corneal damage caused by ultraviolet light. {ECO:0000269PubMed:10376761, ECO:0000269PubMed:11784860}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Constitutively expressed in cornea, stomach, skin, bladder and lungs. Lowest expression levels in lungs and bladder. {ECO:0000269PubMed:10376761}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0008106	alcohol dehydrogenase (NADP+) activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Biological Process

GO:0001666	response to hypoxia
GO:0006081	cellular aldehyde metabolic process
GO:0007568	aging
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0008284	positive regulation of cell proliferation
GO:0014070	response to organic cyclic compound
GO:0042493	response to drug
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1353451

InterPro

IPR008670 Acyl-CoA reductase, LuxC
IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase

PFAM

PF05893
PF00171

PRINTS

PIRSF

PIRSF009414
PIRSF036492

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47739