InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnh3

Summary

InnateDB Protein

IDBP-182443.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnh3

Protein Name

potassium voltage-gated channel, subfamily H (eag-related), member 3

Synonyms

AU019351; C030044P22Rik; Elk2; Kv12.2; Melk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040548

InnateDB Gene

IDBG-182441 (Kcnh3)

Protein Structure

UniProt Annotation

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in brain, but not in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000155	phosphorelay sensor kinase activity
GO:0004871	signal transducer activity
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0007165	signal transduction
GO:0023014	signal transduction by phosphorylation
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1341723

InterPro

IPR000014 PAS domain
IPR000595 Cyclic nucleotide-binding domain
IPR000700 PAS-associated, C-terminal
IPR001610 PAC motif
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR003950 Potassium channel, voltage-dependent, ELK
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
IPR013655 PAS fold-3
IPR013656 PAS fold-4
IPR013767 PAS fold
IPR018490 Cyclic nucleotide-binding-like

PFAM