InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacna2d4

Summary

InnateDB Protein

IDBP-182502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacna2d4

Protein Name

calcium channel, voltage-dependent, alpha 2/delta subunit 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044660

InnateDB Gene

IDBG-182500 (Cacna2d4)

Protein Structure

UniProt Annotation

Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Note=Defects in Cacna2d4 are a cause of cone-rod dysfunction. Mice display affected retinal ribbon-type synapses. The retinopathy is accompanied by a substantial loss in the activities of the second-order neurons. Rod photoreceptor responses are maintained with reduced amplitude, whereas cone activities are absent.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0046872	metal ion binding

Biological Process

GO:0034765	regulation of ion transmembrane transport
GO:0050908	detection of light stimulus involved in visual perception
GO:0070588	calcium ion transmembrane transport