InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il6st

Summary

InnateDB Protein

IDBP-182519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il6st

Protein Name

interleukin 6 signal transducer

Synonyms

5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699e; gp130;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064205

InnateDB Gene

IDBG-182517 (Il6st)

Protein Structure

UniProt Annotation

Function

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver. Found in all the cell lines tested except BaF-B03. Expression not restricted to IL6-responsive cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004915	interleukin-6 receptor activity
GO:0004921	interleukin-11 receptor activity
GO:0004923	leukemia inhibitory factor receptor activity
GO:0004924	oncostatin-M receptor activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0019970	interleukin-11 binding
GO:0019981	interleukin-6 binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0008593	regulation of Notch signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0038154	interleukin-11-mediated signaling pathway
GO:0038165	oncostatin-M-mediated signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045669	positive regulation of osteoblast differentiation
GO:0048711	positive regulation of astrocyte differentiation
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0070102	interleukin-6-mediated signaling pathway
GO:0070104	negative regulation of interleukin-6-mediated signaling pathway
GO:0070106	interleukin-27-mediated signaling pathway
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005896	interleukin-6 receptor complex
GO:0005900	oncostatin-M receptor complex
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0044297	cell body
GO:0070110	ciliary neurotrophic factor receptor complex