InnateDB Protein
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IDBP-182538.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mcrs1
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Protein Name
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microspherule protein 1
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Synonyms
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C78274; ICP22BP; MSP58; P78;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000043901
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InnateDB Gene
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IDBG-182536 (Mcrs1)
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Protein Structure
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Function |
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
55 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0043995
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histone acetyltransferase activity (H4-K5 specific)
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GO:0043996
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histone acetyltransferase activity (H4-K8 specific)
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GO:0046972
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histone acetyltransferase activity (H4-K16 specific)
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1858420
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InterPro |
IPR000253
Forkhead-associated (FHA) domain
IPR008984
SMAD/FHA domain
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PFAM |
PF00498
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PRINTS |
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PIRSF |
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SMART |
SM00240
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TIGRFAMs |
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Modification |
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SwissProt |
Q99L90
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PhosphoSite |
PhosphoSite-Q99L90
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TrEMBL |
Q3TJY1
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UniProt Splice Variant |
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Entrez Gene |
51812
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UniGene |
Mm.383472
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RefSeq |
NP_058046
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MGI ID |
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MGI Symbol |
Mcrs1
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OMIM |
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CCDS |
CCDS37199
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HPRD |
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IMGT |
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EMBL |
AC161198
AF015309
AK088116
AK167242
BC003746
BC085099
BC108340
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GenPept |
AAC53590
AAH03746
AAH85099
AAI08341
BAC40155
BAE39364
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