InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl22

Summary

InnateDB Protein

IDBP-182593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl22

Protein Name

chemokine (C-C motif) ligand 22

Synonyms

ABCD-1; DCBCK; MDC; Scya22;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034231

InnateDB Gene

IDBG-182591 (Ccl22)

Protein Structure

UniProt Annotation

Function

Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B- lymphocytes with T-cells in immune responses.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:1306779

InterPro

IPR001811 Chemokine interleukin-8-like domain

PFAM

PF00048

PRINTS

PIRSF

SMART

SM00199

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88430

PhosphoSite

PhosphoSite-

TrEMBL

Q546S6

UniProt Splice Variant

Entrez Gene

20299

UniGene

Mm.12895

RefSeq

NP_033163

MGI ID

MGI Symbol

Ccl22

OMIM

CCDS

CCDS40441

HPRD

IMGT

EMBL

AF052505 AF076596 AJ238238 AJ315897 AK155083 AK155764 AK156627 AK170080 BC012658 CH466525

GenPept

AAC40200 AAD50547 AAH12658 BAE33035 BAE33426 BAE33782 BAE41551 CAB40894 CAC86953 EDL11143