InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam10

Summary

InnateDB Protein

IDBP-182596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam10

Protein Name

a disintegrin and metallopeptidase domain 10

Synonyms

1700031C13Rik; kuz; kuzbanian; MADM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063839

InnateDB Gene

IDBG-182594 (Adam10)

Protein Structure

UniProt Annotation

Function

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell- surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP) at '687- Lys--Leu-688'. Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10- processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001701	in utero embryonic development
GO:0006468	protein phosphorylation
GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0006913	nucleocytoplasmic transport
GO:0007162	negative regulation of cell adhesion
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0008284	positive regulation of cell proliferation
GO:0010820	positive regulation of T cell chemotaxis
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0034612	response to tumor necrosis factor
GO:0042117	monocyte activation
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis
GO:0051089	constitutive protein ectodomain proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005798	Golgi-associated vesicle
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome
GO:0097038	perinuclear endoplasmic reticulum
GO:0097197	tetraspanin-enriched microdomain